8:30-8:40

Opening

I．Chemical and Biological Perspectives of DNA Modifications
Chair of the first half part:  Kazu Ushijima (Tokyo)

8:40-9:05

A vitamin C-derived DNA modification

Guoliang Xu
(Academia Sinica, Shanghai)

9:05-9:25

Dynamic regulation of DNA methylation

Bing Zhu
(Academia Sinica, Beijing)

9:25-9:50

Active DNA Demethylation by Vertebrate DNA Methyltransferases

James Shen
(Academia Sinica, Taipei)

9:50-10:15

Chemical-assisted Sequencing of Epigenetic Nucleic Acid Modifications

Chengqi Yi
( Peking University)

10:15-10:40

Break+Group Photograph

Chair of the second half part : Fei Lan(FuDan University)

10:40-11:05

Single-cell multi-omic analysis of human organs

Kun Zhang
(UCSD)

11:05-11:30

Structural Insight into dynamic regulation of DNA methylation

Yanhui Xu 
( Fudan University)

11:30-11:40

Epigenome Reprogramming as a Basis for Combination Therapy

Naoko Hattori
(Tokyo,Japan)

11:40-11:50

Short Talk 2

11:50-13:00

Lunch

13:00-14:30

Poster session I

II．Chemical and Biological Perspectives of histone modifications
Chair of the first half part : Youngjun Kim(Korea, Seul)

14:30-14:55

Structure and Function of YEATS Domain in Health and Disease

Haitao Li
(Tsinghua University)，

14:55-15:20

The Dynamic Regulation of Histone Methylation

Fei Lan
(Fudan University)

15:20-15:45

 De-acetylation and Epigenomic regulation

 Ullas Kolthur-Seetharam

（Tata Institute， India）

15:45-16:10

Metabolic regulation of gene expression

Zhimin Lu
(MD Anderson)

16:10-16:30

Tea Break

Chair of the second half part: Lijung Juan(Academia Sinica, Taipei)

16:30-16:55

Epgenetics and Adipogenesis: Implications of Histone modifications Languages

Tapas K. Kundu
(India)

16:55-17:20

Crosstalk between histone modifications  during heterochromatin assembly

Jun-ichi Nakayama
(Japan)

III. Chemical and epigenetic regulation of transcription
Chair of the first half part: Shyam PRABHAKAR (Singapore)

8:30-8:55

R-loopsin physiology and pathology

Xiangdong Fu
(UCSD)

8:55-9:20

Epigenetic Regulation of Hematopoietic Stem Cell Development

Feng Liu
(Academia Sinica, Beijing)

9:20-9:50

The Diversity and Function of Long Noncoding RNAs

Lingling Chen
(Academia Sinica,Shanghai)

9:50-10:15

Cis-acting lncRNAs in transcription and chromatin regulation

Xiaohua Shen
(Tsinghua University)

10:15-10:40

Tea Break

Chair of the second half part: Hongkui Deng(Peking University)

10:40-11:05

R-loop, the general chromatin feature in Arabidopsis genomes

Qianwen Sun
(Tsinghua University)

11:05-11:30

Re-thinking the coding capacity of non-coding RNA

Zefeng Wang
( Academia Sinica，Shanghai)

11:30-11:40

A long noncoding RNA in telomere maintenance, gene regulation and inter-chromosomal pairing

Hsueh-Ping Chu 
(National Taiwan University)

11:40-11:50

Short Talk 4

11:50-13:00

Lunch

13:00-14:30

Poster session 2

IV．Clinical Epigenetics
Chair of the first half part : Tapas Kundu(India)

14:30-14:55

Implication of Long Non-coding RNAs in Cancer Biology

Yutaka Kondo
(Nagoya University, Japan)

14:55-15:20

Enhanced anti-tumor activity of PD1 blockade by DNA demethylating agent in the clinic

Weidong Han
(301 Hospital, Beijing);

15:20-15:45

Talk 21

Teh Bin Tean
(Cancer Center, Singapore),

15:45-16:10

Functional prediction of causal regulatory variants identifies a novel autism gene

Jung Kyoon Choi
(Korea)

16:10-16:30

Tea Break

Chair of the second half part: Zefeng Wang(Academia Sinica)

16:30-16:55

DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA as Diagnostic Biomarkers for Human Cancers

Xingyu Lu
(Shanghai)

16:55-17:20

Drug discovery of protein-protein interactions by targeting epi-modification state of untargetable protein

Cheng Luo
(Academia Sinica，Shanghai)

V．Chemical and biological perspectives of the higher-order chromatin structure
Chair of the first half part: Young-Joon Kim( Korea)

8:30-8:55

Talk 25

Jun-ichi Nakayama
(Tokyo，Japan)

8:55-9:20

Dynamic regulation of higher-order chromatin structures in gene regulation

Guohong Li
(Adademia Sinica, Beijing)

9:20-9:45

Reprogramming of chromatin architecture in early mammalian development

Wei Xie
(Tsinghua University)

9:45-10:10

Combinatorial mechanisms in 3D genome folding and transcription regulation

Yijun Ruan
(Jackson Lab, USA)

10:10-10:30

Tea Break

Chair of the second half part: Lingling Chen(Academia Sinica, Shanghai)

10:30-10:55

Systematic Mapping of RNA-Chromatin Interactions In Vivo

Sheng Zhong
(UCSD)

10:55-11:20

Talk 30

11:20-11:30

Decoding the Epigenetic Landscape by the Histone Readers: Implications in human diseases

Chandrima Das

11:30-11:40

Short talk 6

11:40-13:00

Lunch

VI． Developmental Epigenetics
Chair of the first half part: Guoliang Xu(Academia Sinica, Shanghai)

13:00-13:25

Talk 31

13:25-13:50

CROSSTALK OF N-A-ACETYLTRANSFERASE AND DNA METHYLATION IN DEVELOPMENT AND DISEASE

Li-Jung Juan
(Adademia Sinica,Taipei)

13:50-14:15

Single-cell multi-omics sequencing of mouse early embryos and embryonic stem cells

Fuchou Tang
(Peking University)

14:15-14:25

Short talk 7

14:25-14:35

Short talk 8

14:35-14:45

Short talk 9

14:45-14:55

Short talk 10

14:55-15:15

Tea Break

Chair of the second half part: Xiangdong Fu(UCSD)

15:40-15:50

Short Talk 11

15:50-16:00

Short Talk 12

16:00-16:25

Talk35

16:25-16:50

Small Molecule-induced Cell Fate Reprogramming

Hongkui Deng
(Peking University)

16:50-17:00

Closing